Version:
12.0
Login
Register
Survey
STRING
STRING
Search
Download
Help
My Data
There are several matches for 'invasion protein'.
Please select one from the list below and press Continue to proceed.
<- Back
Continue ->
4462 matches
showing page 1 of 224
•
first
•
previous
•
next
•
last
organism
protein
1)
Homo sapiens
MIIP - Migration and
invasion
-inhibitory
protein
; Inhibits glioma cells
invasion
and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell
invasion
.
[a.k.a. XM_005263487, MIIP-202, URS0000EBF10F]
2)
Homo sapiens
LYPD8 - Ly6/PLAUR domain-containing
protein
8; Secreted
protein
specifically required to prevent
invasion
of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents
invasion
of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.
[a.k.a. LY6/PLAUR domain containing 8, NM_001085474, ENSP00000466070]
3)
Homo sapiens
LRSAM1 - E3 ubiquitin-
protein
ligase LRSAM1; E3 ubiquitin-
protein
ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral
proteins
) cargos. Bacterial recognition
protein
that defends the cytoplasm from
invasive
pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
[a.k.a. Q6UWE0, CCDS6873, AAH09239.1]
4)
Homo sapiens
GNA12 - Guanine nucleotide-binding
protein
subunit alpha-12; Guanine nucleotide-binding
proteins
(G
proteins
) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating
protein
-1) (By similarity). GNA12-dependent Rho signaling also regulates
protein
phosphatese 2A activation causing dephosphorylation of its target
proteins
. Promotes tumor cell
invasion
and metastasis by activating RhoA/ROCK sign [...]
[a.k.a. R-HSA-388396, gep, R-HSA-162582]
5)
Homo sapiens
TIAM1 - T-lymphoma
invasion
and metastasis-inducing
protein
1; Modulates the activity of RHO-like
proteins
and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator
protein
that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
[a.k.a. R-HSA-388396, OTTHUMG00000084869, NP_001340613]
6)
Homo sapiens
TIAM2 - T-lymphoma
invasion
and metastasis-inducing
protein
2; Modulates the activity of RHO-like
proteins
and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator
protein
that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling acc [...]
[a.k.a. R-HSA-388396, ENSP00000443546, ENST00000456877]
7)
Homo sapiens
GNA13 - Guanine nucleotide-binding
protein
subunit alpha-13; Guanine nucleotide-binding
proteins
(G
proteins
) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating
protein
-1) (By similarity). Promotes tumor cell
invasion
and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho a [...]
[a.k.a. L22075, R-HSA-388396, NM_006572]
8)
Homo sapiens
CTSF - Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of
proteins
. Has also been implicated in tumor
invasion
and metastasis.
[a.k.a. ENSP00000433082, CTSF-206, NP_003784]
9)
Homo sapiens
BIRC3 - Baculoviral IAP repeat-containing
protein
3; Multi-functional
protein
which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell
invasion
and metastasis. Acts as an E3 ubiquitin-
protein
ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
proteins
[...]
[a.k.a. hIAP1, R-HSA-162582, R-HSA-5676594]
10)
Homo sapiens
BIRC2 - Baculoviral IAP repeat-containing
protein
2; Multi-functional
protein
which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell
invasion
and metastasis. Acts as an E3 ubiquitin-
protein
ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
protein
[...]
[a.k.a. ENST00000534130, NP_001157, 3UW4]
11)
Homo sapiens
MTBP - Mdm2-binding
protein
; Inhibits cell migration in vitro and suppresses the
invasive
behavior of tumor cells (By similarity). May play a role in MDM2- dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
[a.k.a. MTBP-201, XP_011515264.1, hMTBP]
12)
Homo sapiens
SH3PXD2A - SH3 and PX domain-containing
protein
2A; Adapter
protein
involved in invadopodia and podosome formation, extracellular matrix degradation and
invasiveness
of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer
protein
that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Belongs to the SH3PXD2 family.
[a.k.a. SH3MD1, R-HSA-8941237, NP_055446.2]
13)
Homo sapiens
RAB25 - Ras-related
protein
Rab-25; Involved in the regulation of cell survival. Promotes
invasive
migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2,; Belongs to the small GTPase superfamily. Rab family.
[a.k.a. ENSG00000132698, ENST00000361084.9, EAW53003.1]
14)
Homo sapiens
GPC6 - Secreted glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix
proteins
, proteases and anti-proteases (By similarity). Enhances migration and
invasion
of cancer cells through WNT5A signaling. Belongs to the glypican family.
[a.k.a. R-HSA-388396, R-HSA-196854, R-HSA-975634]
15)
Homo sapiens
SRRM3 - Serine/arginine repetitive matrix
protein
3; May play a role in regulating breast cancer cell
invasiveness
. May be involved in RYBP-mediated breast cancer progression ; Belongs to the CWC21 family.
[a.k.a. A6NNA2, Serine/arginine repetitive matrix protein 3, ENST00000388802]
16)
Homo sapiens
MMP2 - 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor
invasion
, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix
proteins
, can also act on several nonmatrix
proteins
such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...]
[a.k.a. MMP2-207, ENST00000568715, Gelatinase A]
17)
Homo sapiens
ST14 - Suppressor of tumorigenicity 14
protein
; Degrades extracellular matrix. Proposed to play a role in breast cancer
invasion
and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.
[a.k.a. TMPRSS14, ENSG00000149418, 4O9V]
18)
Homo sapiens
TLNRD1 - Talin rod domain-containing
protein
1; Actin-binding
protein
which may have an oncogenic function and regulates cell proliferation, migration and
invasion
in cancer cells.
[a.k.a. hsa:59274, uc002bfz.4, BC084554]
19)
Homo sapiens
NIBAN2 -
Protein
Niban 2; May play a role in apoptosis suppression. May promote melanoma cell
invasion
in vitro.
[a.k.a. OMIM:614045, NIBAN2-202, ENST00000373312]
20)
Homo sapiens
PTPRK - Receptor-type tyrosine-
protein
phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor
invasion
, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
[a.k.a. XM_011536015, URS0000E97CC5, UPI0001747A04]
4462 matches
showing page 1 of 224
•
first
•
previous
•
next
•
last
<- Back
Continue ->